Achtelfinale vom 17.03.2022
| 17.03.2022 18:45 | Galatasaray Istanbul  |
– |  FC Barcelona |
1 | : | 2 |
| 17.03.2022 18:45 | Roter Stern Belgrad  |
– |  Glasgow Rangers |
2 | : | 1 |
| 17.03.2022 18:45 | Bayer 04 Leverkusen  |
– |  Atalanta Bergamo |
0 | : | 1 |
| 17.03.2022 18:45 | AS Monaco  |
– |  Sporting Braga |
1 | : | 1 |
| 17.03.2022 21:00 | Spartak Moskau  |
– |  RB Leipzig |
_ | : | _ |  |
| 17.03.2022 21:00 | West Ham United  |
– |  FC Sevilla |
2 | : | 0 | (n.V.) |
| 17.03.2022 21:00 | Olympique Lyon  |
– |  FC Porto |
1 | : | 1 |
| 17.03.2022 21:00 | Eintracht Frankfurt  |
– |  Real Betis |
1 | : | 1 | (n.V.) |